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 ▼minocycline, ciprof  Keegreewetlok 2010/02/14(日) 09:57

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 ■題名 : minocycline, ciprof
 ■名前 : Keegreewetlok <dumb0909@yandex.ru>
 ■日付 : 2010/02/14(日) 09:57
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   Minocycline-<a href=http://minocycline.us/>minocycline</a> is a widely used antimicrobial agent, especially for the treatment of acne. Long term minocycline therapy is also sometimes used for patients with osteomyelitis or prosthetic-related infection due to methicillin-resistant staphylococci. Various febrile reactions have been reported, some associated with joint, lung, liver, and skin involvement, and often accompanied by eosinophilia. In most of these reports, patients were taking minocycline for many months to years before the reaction occurred; this may result in the drug being overlooked as the cause of the fever...

<a href=http://metronidazole.us/>Metronidazole</a> generally distributes well into body tissues and unlike clindamycin, effectively penetrates the blood-brain barrier. In patients without meningeal inflammation, cerebrospinal fluid (CSF) levels approximate 45 percent of corresponding serum concentrations. Those with meningitis experience similar CSF and serum concentrations. Metronidazole exhibits excellent penetration into brain abscesses, where concentrations approximate that of the serum. Metronidazole also distributes well into muscle tissue of patients with sepsis or those undergoing surgery...

<a href=http://www.flagyl.us/>Flagyl</a> is minimally protein bound, with approximately 80 percent or more circulating as free drug. Concentrations sufficient for therapeutic activity are achieved in hepatic abscesses as well as alveolar bone. Among patients with common bile duct obstruction, flagyl concentrations in the common bile duct following intravenous administration were reportedly 56 to 99 percent that of serum. Among patients with gallstones but preserved gallbladder function and among those with absent gallbladder function but a patent cystic duct, metronidazole concentrations in the gallbladder bile, common duct bile, and serum were similar. By contrast, little to no flagyl was recovered from gallbladder bile among patients who had a stone blocking the cystic duct...

Fluconazole-Available in both oral and intravenous preparations, <a href=http://fluconazole.us/>fluconazole</a> is very hydrophilic and almost completely absorbed following oral administration; the reported bioavailability is over 90 percent. Fluconazole's absorption is not affected by the presence of food or gastric pH. There is also an intravenous preparation, which is useful if gastrointestinal absorption or motility is impaired. A single dose of fluconazole is widely distributed into body fluids and tissues, with only 10 to 12 percent being protein bound. High concentrations can be measured in urine as well as prostatic tissues. Fluconazole distributes well into the cerebrospinal fluid (CSF), with levels reaching 60 to 80 percent of serum levels. Fluconazole achieves concentrations in the vitreous body of 20 to 70 percent that in the serum.

<a href=http://ciprofloxacin.us/>Ciprofloxacin</a> and other quinolones-Fluoroquinolones are highly active in vitro against most gram-negative organisms that cause meningitis. The use of ciprofloxacin in the treatment of meningitis has been the topic of several reviews; ciprofloxacin or pefloxacin therapy was curative in more than 50 cases of meningitis to date. There have also been case reports describing the successful use of ciprofloxacin in neonates with meningitis caused by multiply resistant gram-negative bacilli, in some of these cases ciprofloxacin concentrations in the CSF exceeded 50 percent of serum concentrations. An early review of ciprofloxacin for the treatment of gram-negative bacillary meningitis in adults reported a 90 percent cure rate (18 out of 20 patients), with rapid sterilization of the CSF...

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